Calcineurin inhibitors and calcineurin-NFAT system
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation by calcium, calcineurin, and NFAT.
References http://genesdev.cshlp.org/content/17/18/2205.full.html#related-urls Article cited in: http://genesdev.cshlp.org/content/17/18/2205.full.html#ref-list-1 This article cites 216 articles, 121 of which can be accessed free at: service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the Collec...
متن کاملCalcineurin/NFAT signaling in lymphoid malignancies.
Deregulated calcium signaling is observed at different stages of tumorigenic processes. An important signaling pathway activated in response to calcium involves the protein phosphatase calcineurin and NFAT transcriptional factors. We review here recent data that indicate an important role of the calcineurin/NFAT pathway in lymphoma/leukemogenesis and discuss the potential therapeutic implicatio...
متن کاملCalcineurin/NFAT signalling inhibits myeloid haematopoiesis
Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signalling can also mediate granulocyte and dendritic cell (DC) activation, but it is unknown whether NFAT influences their development from progenitors. Here, we report a novel role for calcineurin/NFAT signalling as a negative regulator ...
متن کاملThe calcineurin-NFAT pathway negatively regulates megakaryopoiesis.
The calcium regulated calcineurin-nuclear factor of activated T cells (NFAT) pathway modulates the physiology of numerous cell types, including hematopoietic. Upon activation, calcineurin dephosphorylates NFAT family transcription factors, triggering their nuclear entry and activation or repression of target genes. NFATc1 and c2 isoforms are expressed in megakaryocytes. Moreover, human chromoso...
متن کاملHow calcineurin inhibitors cause hypertension.
Calcineurin is a calcium-dependent serine–threonine protein phosphatase. Calcineurin activates the nuclear factor of activated T-cells cytoplasmic (NFAT)c, a transcription factor, by dephosphorylating the protein. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2010
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.33.249